目前来自美国、中国和日本的研究人员经过合作,代谢应激下名为Atg7的基因能够调节抑癌基因p53的活性进而控制细胞周期和细胞存活。

-2012年4月13日《科学》


中文翻译


【题目】:代谢应激下Atg7调节p53的活性进而控制细胞周期和细胞存活

【译文】:营养物的缺乏会导致细胞退出分裂周期,诱导自我吞噬,甚至激活细胞死亡程序。这些事件之间的关系在任何情况下都不好描述。我们发现饥饿的小鼠胚胎纤维母细胞由于缺乏自我吞噬作用所必须的基因产物Atg7,就不能停止细胞分裂周期。Atg7除了自身的类似E1酶活性外,它还能结合肿瘤抑制基因p53,从而调控编码细胞周期抑制物p21CDKN1A基因的翻译过程。在持续的代谢应激下,Atg7的缺乏导致由p53依赖性细胞凋亡引起的大片段DNA损伤。由除去蛋白激酶Chk2引起的抑制DNA损伤能够挽救部分出生后致命性的Atg7—/—缺陷小鼠。因此,在细胞营养物有限的情况下,Atg7能够调节p53依赖性细胞周期和细胞死亡途径。
英文原稿



[Title]:Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

[Author]:In Hye Lee, Yoshichika Kawai, Maria M. Fergusson, Ilsa I. Rovira1, Alexander J. R. Bishop, Noboru Motoyama, Liu Cao, Toren Finkel

[Abstract]:Withdrawal of nutrients triggers an exit from the cell division cycle, the induction of autophagy, and eventually the activation of cell death pathways. The relation, if any, among these events is not well characterized. We found that starved mouse embryonic fibroblasts lacking the essential autophagy gene product Atg7 failed to undergo cell cycle arrest. Independent of its E1-like enzymatic activity, Atg7 could bind to the tumor suppressor p53 to regulate the transcription of the gene encoding the cell cycle inhibitor p21CDKN1A. With prolonged metabolic stress, the absence of Atg7 resulted in augmented DNA damage with increased p53-dependent apoptosis. Inhibition of the DNA damage response by deletion of the protein kinase Chk2 partially rescued postnatal lethality in Atg7−/− mice. Thus, when nutrients are limited, Atg7 regulates p53-dependent cell cycle and cell death pathways.

原文地址

http://www.sciencemag.org/content/336/6078/225.abstract

本站声明: 生物文库所有文章欢迎转载,所有文章未说明,均属于原创,转载均请注明出处。
本文链接: http://www.bioku.cn/201204/science-atg7-p53-cell-cycle/
版权所有: 生物文库 - 生物医学、生物技术核心期刊文摘

1 条回复 » to “《Science》2012.04.13-代谢应激下Atg7调节p53的活性进而控制细胞周期和细胞存活”

  1. Burton Hazzard 说道:

    I simply want to say I am beginner to blogging and actually savored your web site. Most likely I’m likely to bookmark your site . You surely come with fantastic stories. Thanks a bunch for revealing your website page.

留言


8 − 二 =


沪ICP备12028140号
点击这里给我发消息   点击这里给我发消息