来自美国哥伦比亚大学,微生物学和免疫学系的Sankar Ghosh实验室发现tlr11−/−型小鼠可以作为研究对S. Typhi产生免疫应答的小模式动物,本篇文章刊登在最新一期《CELL》杂志上。

-2012年10月26日《细胞》


中文翻译


【题目】 Salmonella Typhi感染的小鼠模型

【译文】Salmonella spp.是有鞭毛的革兰氏阴性细菌,这种细菌可以引起人类胃肠炎和伤寒病。我们在小鼠肠道中的Toll样受体11(TLR11)中发现来自于Salmonella spp.的鞭毛。缺乏TLR11使得小鼠更易感染S. Typhimurium,并且提高了细菌的传播率和致死率。不同于S. Typhimurium,S. Typhi作为一种人类专性病原体可以引起伤寒病而这种病原体不能感染小鼠。TLR11在小鼠中表达而不在人类中表达,值得注意的是我们发现tlr11−/−型小鼠可以经口服感染S. Typhi。我们同时发现tlr11−/−型小鼠可以对S. Typhi产生免疫作用。因此,tlr11−/−型小鼠可以作为研究对S. Typhi产生免疫应答的小模式动物,且这对于人类病原体疫苗的研究有很重要的作用。

英文原稿


[Title]A Mouse Model of Salmonella Typhi Infection

[Authors]Ramkumar Mathur, Hyunju Oh, Dekai Zhang, Sung-Gyoo Park, Jin Seo, Alicia Koblansky, Matthew S. Hayden, Sankar Ghosh

[Abstract]Salmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne gastroenteritis and typhoid fever in humans. We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11). Absence of TLR11 renders mice more susceptible to infection by S. Typhimurium, with increased dissemination of the bacteria and enhanced lethality. Unlike S. Typhimurium, S. Typhi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice. TLR11 is expressed in mice, but not in humans, and remarkably, we find that tlr11−/− mice are efficiently infected with orally administered S. Typhi. We also find that tlr11−/− mice can be immunized against S. Typhi. Therefore, tlr11−/− mice represent a small-animal model for the study of the immune response to S. Typhi and for the development of vaccines against this important human pathogen.

原文地址

http://www.cell.com/abstract/S0092-8674(12)01176-2

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