来自美国的Vaidya等人展示了RNA装配的自发性协作网络,协作可以使四个不同RNA片段装配成为更长的核酶,从而提出生命起源于分子间的自发协作。文章主要对三个RNA片段的协作环路进行了详细描述,数据显示可能还存在更大的协作网络。

-2012年11月1日《自然》

中文翻译


【题目】协作的RNA复制子间的自发形成协作网络

【译文】地球上生命的起源需要建立具有维持和进化生物学信息能力的自我复制的化学系统。在RNA世界中,单个自我复制的RNA将面临具有较低突变率足以维持它们自己的信息并成功对抗有限进化能力分子寄生虫的突变率。因此理论分析表明相互作用分子网络更易发展并维持生命样行为。本研究表明自我组装成自主复制核酶的RNA片段混合物自发地形成协作催化性循环和网络。我们发现一种特异性三成员网络具有高度协作的生长活性。当这样的协作网络直接与自身催化循环竞争,前者生长更快,表明RNA群体通过协作发展为更具复杂网络的内在能力。我们观察到通过体外筛选的网络进化能力。我们的实验阐明了新生生命分子阶段合作行为事件的优势。

英文原稿


[Title]: Spontaneous network formation among cooperative RNA replicators

[Authors]:Nilesh Vaidya,1 Michael L. Manapat,2 Irene A. Chen,3, 5 Ramon Xulvi-Brunet,3 Eric J. Hayden4 & Niles Lehman1

[Abstract]:The origins of life on Earth required the establishment of self-replicating chemical systems capable of maintaining and evolving biological information. In an RNA world, single self-replicating RNAs would have faced the extreme challenge of possessing a mutation rate low enough both to sustain their own information and to compete successfully against molecular parasites with limited evolvability. Thus theoretical analyses suggest that networks of interacting molecules were more likely to develop and sustain life-like behaviour. Here we show that mixtures of RNA fragments that self-assemble into self-replicating ribozymes spontaneously form cooperative catalytic cycles and networks. We find that a specific three-membered network has highly cooperative growth dynamics. When such cooperative networks are competed directly against selfish autocatalytic cycles, the former grow faster, indicating an intrinsic ability of RNA populations to evolve greater complexity through cooperation. We can observe the evolvability of networks through in vitro selection. Our experiments highlight the advantages of cooperative behaviour even at the molecular stages of nascent life.

原文地址

http://www.nature.com/nature/journal/v491/n7422/full/nature11549.html

本站声明: 生物文库所有文章欢迎转载,所有文章未说明,均属于原创,转载均请注明出处。
本文链接: http://www.bioku.cn/201212/nature-spontaneous-network-self-replicating-rnas-cooperation/
版权所有: 生物文库 - 生物医学、生物技术核心期刊文摘

留言


× 一 = 4


沪ICP备12028140号
点击这里给我发消息   点击这里给我发消息