来自法国居里研究院的Luigia Pace及其同事发现调节性T细胞(Treg)能够增强T细胞的亲和力,因此促进了T细胞响应异己抗原而不响应自身抗原。

-2012年10月26日《科学》

中文翻译


【题目】调节性T细胞增强原发性CD8+ T细胞反应并促进记忆

【译文】尽管人们都知道调节性T细胞(Tregs)能够抑制自我反应的自体免疫反应,但Tregs在T细胞响应异己抗原过程中的作用还未充分理解。本研究表明Tregs在小鼠的免疫响应启动过程中具有关键的作用。由于CCL-3/4/5趋化因子的过度分泌,机体缺失Treg会诱导低亲和力的CD8+ T细胞群的激活和增殖,结果稳定了呈递抗原的树突细胞与低亲和力的T细胞之间的相互作用。缺乏Tregs时,初次免疫响应的亲和力受损,导致机体对单核细胞增生利斯特菌(Listeria monocytogenes)的免疫记忆降低。这些研究表明Tregs是CD8+ T细胞启始稳态的重要调节因素,且它在高亲和力的初次免疫响应和有效的免疫记忆中具有关键的作用。

英文原稿


[Title]: Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

[Authors]: Luigia Pace, Andy Tempez, Catharina Arnold-Schrauf, Fabrice Lemaitre, Philippe Bousso, Luc Fetler, Tim Sparwasser, and Sebastian Amigorena

[Abstract]: Although regulatory T cells (Tregs) are known to suppress self-reactive autoimmune responses, their role during T cell responses to nonself antigens is not well understood. We show that Tregs play a critical role during the priming of immune responses in mice. Treg depletion induced the activation and expansion of a population of low-avidity CD8+ T cells because of overproduction of CCL-3/4/5 chemokines, which stabilized the interactions between antigen-presenting dendritic cells and low-avidity T cells. In the absence of Tregs, the avidity of the primary immune response was impaired, which resulted in reduced memory to Listeria monocytogenes. These results suggest that Tregs are important regulators of the homeostasis of CD8+ T cell priming and play a critical role in the induction of high-avidity primary responses and effective memory.

原文地址

http://www.sciencemag.org/content/338/6106/532.short

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