nature-genetic201211-7

来自上海第二军医大学的Yinghao Sun教授及其同事报道了对汉人前列腺癌的全基因组关联研究结果。他们在染色体9q31和19q13上鉴定到两个新易感位点。这项研究有助于加深对前列腺癌的遗传易感性的理解。相关的研究论文于9月30日在线发表在《Nature Genetics》期刊上。

-2012年11月《自然-遗传》

中文翻译


【题目】全基因组关联研究在中国人的9q31.2和19q13.4染色体区域内鉴定到两个新前列腺癌风险位点

【译文】对有欧洲血统、非裔美国人和日本人的全基因组关联研究(GWAS)中,已经有前列腺癌风险相关的变异被报道。为了在中国人中系统地研究前列腺癌风险相关的变异,本研究对中国男性进行了首次的全基因组关联研究。除此之外,还为了证实在其他血统人群中发现的一些关联位点,本次研究(包括4484例前列腺癌患者和8934例正常个体)在染色体9q31.2(rs817826,P = 5.45×10−14)和19q13.4(rs103294,P = 5.34×10−16)上鉴定到与前列腺癌相关的两个新风险相关位点。19q13.4染色体区域上的rs103294标记与一段长6.7kb的生殖细胞系缺失(LILRA3基因(调控炎症反应的基因)的前六七个外显子缺失)保持强烈的连锁平衡,还与T细胞中LILRA3基因的mRNA表达明显相关。这些发现可能有助于加深对前列腺癌的遗传易感性的理解。

英文原稿


[Title]: Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4 

[Authors]: Jianfeng Xu, Zengnan Mo, Dingwei Ye, Meilin Wang, Fang Liu, Guangfu Jin, Chuanliang Xu, Xiang Wang, Qiang Shao, Zhiwen Chen, Zhihua Tao, Jun Qi, Fangjian Zhou, Zhong Wang, Yaowen Fu, Dalin He, Qiang Wei, Jianming Guo, Denglong Wu, Xin Gao, Jianlin Yuan, Gongxian Wang, Yong Xu, Guozeng Wang, Haijun Yao, Pei Dong, Yang Jiao, Mo Shen, Jin Yang, Jun Ou-Yang, Haowen Jiang, Yao Zhu, Shancheng Ren, Zhengdong Zhang, Changjun Yin, Xu Gao, Bo Dai, Zhibin Hu, Yajun Yang, Qijun Wu, Hongyan Chen, Peng Peng, Ying Zheng, Xiaodong Zheng, Yongbing Xiang, Jirong Long, Jian Gong, Rong Na, Xiaoling Lin, Hongjie Yu, Zhong Wang, Sha Tao, Junjie Feng, Jishan Sun, Wennuan Liu, Ann Hsing, Jianyu Rao, Qiang Ding, Fredirik Wiklund, Henrik Gronberg, Xiao-Ou Shu, Wei Zheng, Hongbing Shen, Li Jin, Rong Shi, Daru Lu, Xuejun Zhang, Jielin Sun, S Lilly Zheng & Yinghao Sun

[Abstract]: Prostate cancer risk–associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk–associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10−14) and 19q13.4 (rs103294, P = 5.34 × 10−16) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10−4). These findings may advance the understanding of genetic susceptibility to prostate cancer.

原文地址

http://www.nature.com/ng/journal/v44/n11/full/ng.2424.html

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