来自马普研究所的研究人员开发出了一种多元的方法,名为“神经事件触发的功能性磁共振成像”技术(NET-fMRI),使用此项技术,研究者就可以对麻醉、苏醒甚至是活动中的猴子进行扫描检测其大脑活性的情况。

-2012年11月22日《自然》

中文翻译


【题目】皮层下沉默时期海马-皮质相互作用

【译文】海马脉动是主要发生在睡眠和平静期的间歇性高频场电位波动,已在小鼠、大鼠、兔子、猴及人类中得到研究,而且到目前为止已有研究发现它们与先前获得的唤醒经历的记忆相关。尽管利用神经生理学方法对海马脉动展开了详细的研究,但脉动对整个脑部的总体影响还不清楚,主要是因为缺乏一种可以实现共同海马记录和全脑活动图谱的方法。通过结合海马中的电生理记录和脉动触发的功能性核磁共振成像技术,本研究表明大多数大脑皮层在脉动期间被选择性激活,而多数间脑、中脑及脑干区被强烈及持续地抑制。对局部暂时反应模式的分析表明丘脑活性抑制处于海马群爆发之前,而其自身被相关及主要皮层区的大量活化而暂时地被限制了。 这些发现表明在离线记忆合并期间,协同的丘脑-皮层活性可能精心协调海马和皮质之间的特殊相互作用状态,而这是通过感觉加工过程中或潜在介导程序性学习的皮层下中心的沉默形成的。这样一种机制可能产生最低限度的干扰,使得海马依赖性记忆得到巩固。

英文原稿


[Title]: Hippocampal–cortical interaction during periods of subcortical silence

[Authors]:N. K. Logothetis,1, 2 O. Eschenko,1 Y. Murayama,1 M. Augath,1 T. Steudel,1 H. C. Evrard,1 M. Besserve1, 3 & A. Oeltermann1

[Abstract]Hippocampal ripples, episodic high-frequency field-potential oscillations primarily occurring during sleep and calmness, have been described in mice, rats, rabbits, monkeys and huma ns, and so far they have been associated with retention of previously acquired awake experience. Although hippocampal ripples have been studied in detail using neurophysiological methods, the global effects of ripples on the entire brain remain elusive, primarily owing to a lack of methodologies permitting concurrent hippocampal recordings and whole-brain activity mapping. By combining electrophysiological recordings in hippocampus with ripple-triggered functional magnetic resonance imaging, here we show that most of the cerebral cortex is selectively activated during the ripples, whereas most diencephalic, midbrain and brainstem regions are strongly and consistently inhibited. Analysis of regional temporal response patterns indicates that thalamic activity suppression precedes the hippocampal population burst, which itself is temporally bounded by massive activations of association and primary cortical areas. These findings suggest that during off-line memory consolidation, synergistic thalamocortical activity may be orchestrating a privileged interaction state between hippocampus and cortex by silencing the output of subcortical centres involved in sensory processing or potentially mediating procedural learning. Such a mechanism would cause minimal interference, enabling consolidation of hippocampus-dependent memory.

原文地址

http://www.nature.com/nature/journal/v491/n7425/full/nature11618.html

 

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