来自日本大阪大学的研究人员日前揭示了血管发生在神经重布线中的重要功能,并表明前列环素是增强从CNS疾病的功能性恢复的分子。

-2012年11月《自然-医学》

中文翻译


【题目】CNS炎症诱导的血管发生通过血管来源的前列环素促进神经重塑

【译文】血管发生是中枢神经系统(CNS)疾病的主要特征之一,并在炎症的持续和后续修复过程中发挥作用。本研究报道了源于新生血管的前列环素(或者前列腺素I2 (PGI2))可以在CNS炎症后促进损伤神经网络的轴突重塑。在实验性自身免疫性脑脊髓炎(EAE)局部模型中,在炎性病变周围新生血管形成,随后是临近皮质延髓束(CST)纤维的萌发。这些萌发的纤维形成一种代偿性运动回路,引起运动机能的恢复。毛细管内皮细胞来源的前列环素在CST神经元上与其受体结合,即I型前列腺素受体(IP受体),促进CST纤维的萌发并有助于修复过程。 诱导EAE后,抑制前列环素受体信号会损害运动机能恢复。这些发现揭示了血管发生在神经重布线中的重要功能,表明前列环素是增强从CNS疾病的功能性恢复的分子。

英文原稿


[Title]: Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin

[Authors]:Rieko Muramatsu,1, 2 Chisato Takahashi,1, 2 Shuzo Miyake,1, 2 Harutoshi Fujimura,3 Hideki Mochizuki2, 4 & Toshihide Yamashita1, 2

[Abstract]Angiogenesis is a prominent feature of central nervous system (CNS) disease and has roles in both the continued promotion of inflammation and the subsequent repair processes. Here we report that prostacyclin (or prostaglandin I2 (PGI2)) derived from new vessels promotes axonal remodeling of injured neuronal networks after CNS inflammation. In a localized model of experimental autoimmune encephalomyelitis (EAE), new vessels formed around the inflammatory lesion, followed by sprouting of adjacent corticospinal tract (CST) fibers. These sprouting fibers formed a compensatory motor circuit, leading to recovery of motor function. Capillary endothelial cell–derived prostacyclin bound to its receptor, the type I prostaglandin receptor (IP receptor), on CST neurons, promoting sprouting of CST fibers and contributing to the repair process. Inhibition of prostacyclin receptor signaling impaired motor recovery, whereas the IP receptor agonist iloprost promoted axonal remodeling and motor recovery after the induction of EAE. These findings reveal an important function of angiogenesis in neuronal rewiring and suggest that prostacyclin is a promising molecule for enhancing functional recovery from CNS disease.    

原文地址

http://www.nature.com/nm/journal/v18/n11/abs/nm.2943.html

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