nature20121206-4

来自加州大学伯克利分校分子与细胞生物学系的研究人员利用系统生物学方法,针对包含有多种保守型基因的被囊动物,分析了发育的基因调控网络结构在物种间的进化,指出了神经嵴这一关键结构的进化机制,为进一步解析物种发育进化提供了重要信息。

-2012年12月6日《自然》

中文翻译


【题目】非脊椎动物脊髓动物中未发育神经嵴的鉴定

【译文】神经嵴出现在神经板边缘,表达一组核心调控基因,并产生很多不同的细胞类型,包括加工脊椎动物头部的外胚层间充质衍生物。神经嵴的进化被认为是导致新细胞类型出现的关键事件,而新细胞类型的出现产生了从滤食性的转位以激活原始脊椎动物的捕食行为。然而,关于神经嵴的起源还存在分歧,因为同源细胞类型还未在非脊椎动物的脊髓动物中被清楚地鉴定出来。本研究表明被囊动物海鞘具有一种类似于神经嵴的头侧黑素细胞系,这种细胞系可通过Twist的靶向错误表达而被重编程为迁移的外胚层间充质。我们的结果表明神经嵴黑素细胞调控网络先于被囊动物和脊椎动物的进化分歧。我们提出神经板外胚层中间充质决定因素(如Twist)的共选择对于脊椎动物“新头部”出现至关重要。

英文原稿


[Title]: Identification of a rudimentary neural crest in a non-vertebrate chordate

[Authors]:Philip Barron Abitua,1 Eileen Wagner,1 Ignacio A. Navarrete1 & Michael Levine1

[Abstract]Neural crest arises at the neural plate border, expresses a core set of regulatory genes and produces a diverse array of cell types, including ectomesenchyme derivatives that elaborate the vertebrate head. The evolution of neural crest has been proposed to be a key event leading to the appearance of new cell types that fostered the transition from filter feeding to active predation in ancestral vertebrates. However, the origin of neural crest remains controversial, as homologous cell types have not been unambiguously identified in non-vertebrate chordates. Here we show that the tunicate Ciona intestinalis possesses a cephalic melanocyte lineage (a9.49) similar to neural crest that can be reprogrammed into migrating ‘ectomesenchyme’ by the targeted misexpression of Twist (also known as twist-like 2). Our results suggest that the neural crest melanocyte regulatory network pre-dated the divergence of tunicates and vertebrates. We propose that the co-option of mesenchyme determinants, such as Twist, into the neural plate ectoderm was crucial to the emergence of the vertebrate ‘new head’.

原文地址

http://www.nature.com/nature/journal/v492/n7427/full/nature11589.html

 

本站声明: 生物文库所有文章欢迎转载,所有文章未说明,均属于原创,转载均请注明出处。
本文链接: http://www.bioku.cn/201301/nature-neural-crest-vertebrate-chordate-ciona-intestinalis/
版权所有: 生物文库 - 生物医学、生物技术核心期刊文摘

留言


+ 九 = 11


沪ICP备12028140号
点击这里给我发消息   点击这里给我发消息