美国耶鲁大学科学家的研究显示显示果蝇触须中相邻的嗅觉神经元可以相互阻断,即使二者并没通过突触直接相连。这种通讯手段被称为ephaptic coupling,神经元通过电场使其邻居沉默,而不是通过突触传递神经递质。

-2012年12月6日《自然》

中文翻译


【题目】嗅觉回路中成簇神经元之间的非突触抑制

【译文】不同感觉器官,包括哺乳动物味蕾和昆虫化学感受器,都表现出一种显著的受体细胞区室化作用;然而,这种组织的功能影响尚不清楚。本研究表明区室化的果蝇嗅觉受体神经元(ORN)相互之间直接传送信息。一个ORN的持续性反应被临近ORN的瞬间活化所抑制。从机制上说,这样的横向抑制作用不依赖于突触,可能是通过假突触偶合所介导的。而且,外周中的横向抑制可以调控嗅觉行为。总之,该结果表明嗅觉信息的整合可以通过ORN间的横向相互作用而发生。通过瞬间反应对持续反应的抑制可能提供了一种编码突出性的途径。最后,疟疾虫媒介按蚊中CO2敏感的ORN也可以通过临近ORN的激活而被抑制,这表明横向抑制在昆虫中广泛存在,并可能在昆虫的控制中有所应用。

英文原稿


[Title]: Non-synaptic inhibition between grouped neurons in an olfactory circuit

[Authors]:Chih-Ying Su,1 Karen Menuz,1 Johannes Reisert2 & John R. Carlson1

[Abstract]Diverse sensory organs, including mammalian taste buds and insect chemosensory sensilla, show a marked compartmentalization of receptor cells; however, the functional impact of this organization remains unclear. Here we show that compartmentalized Drosophila olfactory receptor neurons (ORNs) communicate with each other directly. The sustained response of one ORN is inhibited by the transient activation of a neighbouring ORN. Mechanistically, such lateral inhibition does not depend on synapses and is probably mediated by ephaptic coupling. Moreover, lateral inhibition in the periphery can modulate olfactory behaviour. Together, the results show that integration of olfactory information can occur via lateral interactions between ORNs. Inhibition of a sustained response by a transient response may provide a means of encoding salience. Finally, a CO2-sensitive ORN in the malaria mosquito Anopheles can also be inhibited by excitation of an adjacent ORN, suggesting a broad occurrence of lateral inhibition in insects and possible applications in insect control.

原文地址

http://www.nature.com/nature/journal/v492/n7427/full/nature11712.html

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