来自英国国立医学研究所的科学家在最新的研究中指出肠道菌会使免疫缺陷型小鼠基因组中的古代病毒复活,并且导致癌症发生。

-2012年11月29日《自然》

中文翻译


【题目】抗体缺陷小鼠中内源性逆转录病毒的复活

【译文】哺乳动物宿主已经与相当数量的微生物物种之间发展出一种长期共存关系。这些包括环境表面(例如呼吸道和胃肠道)上的微生物群,以及内源性逆转录病毒(ERVs),由相当大一部分哺乳动物基因组组成。宿主与这些微生物物种相互作用的长期结果可以从共生到寄生关系,且尚未完全清楚。一种微生物共生体对另一种的潜在影响一点也不清楚。本研究探究了通常使用的C57BL/6 (B6)小鼠中ERV的控制,该小鼠的细胞中缺乏可以复制的内源性鼠白血病病毒(MLVs)。我们证实了具有一系列影响抗体产生的不同免疫缺陷的B6小鼠中存在完全感染性的嗜亲性MLV的自发出现。这些重组逆转录病毒在免疫缺陷小鼠克隆群中产生感染,并最终导致逆转录病毒诱导的淋巴瘤。值得注意的是,免疫缺陷小鼠中ERV活化在与肠道微生物群减少或缺陷相关的饲养条件下被阻碍了。我们的结果阐明了免疫在控制ERV中的先前未知的作用,并为微生物触发的免疫活化与一系列与ERV相关的病理(包括癌症)之间提供了一种潜在的机制联系。

英文原稿


[Title]: Resurrection of endogenous retroviruses in antibody-deficient mice

[Authors]:George R. Young,1 Urszula Eksmond,1 Rosalba Salcedo,2 Lena Alexopoulou,3 Jonathan P. Stoye4 & George Kassiotis1

[Abstract]The mammalian host has developed a long-standing symbiotic relationship with a considerable number of microbial species. These include the microbiota on environmental surfaces, such as the respiratory and gastrointestinal tracts, and also endogenous retroviruses (ERVs), comprising a substantial fraction of the mammalian genome. The long-term consequences for the host of interactions with these microbial species can range from mutualism to parasitism and are not always completely understood. The potential effect of one microbial symbiont on another is even less clear. Here we study the control of ERVs in the commonly used C57BL/6 (B6) mouse strain, which lacks endogenous murine leukaemia viruses (MLVs) able to replicate in murine cells. We demonstrate the spontaneous emergence of fully infectious ecotropic MLV in B6 mice with a range of distinct immune deficiencies affecting antibody production. These recombinant retroviruses establish infection of immunodeficient mouse colonies, and ultimately result in retrovirus-induced lymphomas. Notably, ERV activation in immunodeficient mice is prevented in husbandry conditions associated with reduced or absent intestinal microbiota. Our results shed light onto a previously unappreciated role for immunity in the control of ERVs and provide a potential mechanistic link between immune activation by microbial triggers and a range of pathologies associated with ERVs, including cancer.

原文地址

http://www.nature.com/nature/journal/v491/n7426/full/nature11599.html

 

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