来自埃默里大学Yerkes国家灵长类动物研究中心的科学家们在猕猴大脑中发现了网格细胞,这些神经元细胞在眼睛探查视觉场景时以重复的三角模式激发。这是第一次直接在灵长类动物中检测到网格细胞。

-2012年11月29日《自然》

中文翻译


【题目】灵长类内嗅皮质的视觉空间图谱

【译文】海马结构神经元中场所调控的活性为服务于记忆形成和回忆的背景信息的组织提供了一种方法。一种特殊的空间表述,即网格细胞,已在大鼠和蝙蝠的内嗅皮质(EC)中被发现,但还没有在灵长类中以单个单位的方式被加以研究。本研究检测了执行无观察视觉记忆任务的头部固定的猴子EC中的空间表述。 单个神经元在灵长类EC中被加以鉴定,当猴子注视视野中每个呈现许多复杂图像的多种离散位置时,这些EC会产生动作单位。这些发射领域具有类似于三角激发模式的空间周期性,并具有空间自相关中相应的定义明确的六角形结构。而且,这些神经元表现出theta谱带的振荡活性,并改变空间范围,作为距鼻沟距离的一种功能,这与先前在啮齿类中的发现一致。这些空间表述可能为锚定复杂可视场景中刺激物含量的编码提供一个框架。总之,我们的研究结果提供了灵长类中存在网格细胞的直接证据,并表明EC神经元在视觉探测期间编码了空间,即便是在没有移动的情况下。 

英文原稿


[Title]: A map of visual space in the primate entorhinal cortex

[Authors]:Nathaniel J. Killian,1, 2 Michael J. Jutras1 & Elizabeth A. Buffalo1, 3

[Abstract]Place-modulated activity among neurons in the hippocampal formation presents a means to organize contextual information in the service of memory formation and recall. One particular spatial representation, that of grid cells, has been observed in the entorhinal cortex (EC) of rats and bats, but has yet to be described in single units in primates. Here we examined spatial representations in the EC of head-fixed monkeys performing a free-viewing visual memory task. Individual neurons were identified in the primate EC that emitted action potentials when the monkey fixated multiple discrete locations in the visual field in each of many sequentially presented complex images. These firing fields possessed spatial periodicity similar to a triangular tiling with a corresponding well-defined hexagonal structure in the spatial autocorrelation. Further, these neurons showed theta-band oscillatory activity and changing spatial scale as a function of distance from the rhinal sulcus, which is consistent with previous findings in rodents. These spatial representations may provide a framework to anchor the encoding of stimulus content in a complex visual scene. Together, our results provide a direct demonstration of grid cells in the primate and suggest that EC neurons encode space during visual exploration, even without locomotion.

原文地址

http://www.nature.com/nature/journal/v491/n7426/full/nature11587.html

本站声明: 生物文库所有文章欢迎转载,所有文章未说明,均属于原创,转载均请注明出处。
本文链接: http://www.bioku.cn/201301/nature-visual-space-primate-entorhinal-cortex/
版权所有: 生物文库 - 生物医学、生物技术核心期刊文摘

留言


九 × = 63


沪ICP备12028140号
点击这里给我发消息   点击这里给我发消息