nature20121220-7

来自美国马萨诸塞大学医学院的科学家日前研究发现蝇类具有受到章鱼胺协同调控的不同多巴胺神经元亚群。

-2012年12月20日《自然》


中文翻译


【题目】果蝇中通过章鱼胺和多巴胺传递的分层奖赏信号

【译文】哺乳动物中多巴胺水平等同于奖赏和动机。然而,近期研究表明果蝇中多巴胺与动机性行为和奖赏增强相关。相反,一直以来,章鱼胺被认为是昆虫中的奖赏信号。利用果蝇中神经功能的时序控制,本研究表明仅仅短期食欲记忆是通过章鱼胺增强的。此外,章鱼胺依赖的记忆形成需要通过多巴胺神经元信号。在已鉴定的蕈形体靶向的多巴胺神经元亚群中,部分章鱼胺信号需要α-肾上腺素能样OAMB受体。这些多巴胺神经元中,章鱼胺触发胞内钙离子增加,而且它们的直接激活可以代替糖以形成食欲记忆,甚至是在缺乏章鱼胺的蝇类中。分析β-肾上腺素能样OCTβ2R受体揭示了章鱼胺依赖的增强也需要与控制食欲动机的多巴胺神经元之间的相互作用。这些数据表明甜味促使了一种分布的章鱼胺信号,这种信号可以通过不同亚类蕈形体靶向的多巴胺神经元增强记忆。此外,它们使先前对多巴胺和章鱼胺的研究相一致,并表明蝇类中增强系统比之前认为的要更加类似哺乳动物。

英文原稿


[Title]: Layered reward signalling through octopamine and dopamine in Drosophila

[Authors]:Christopher J. Burke,1, 5 Wolf Huetteroth,2, 5 David Owald,2 Emmanuel Perisse,2 Michael J. Krashes,1, 6 Gaurav Das,2 Daryl Gohl,3 Marion Silies,3 Sarah Certel4 & Scott Waddell1, 2

[Abstract]:Dopamine is synonymous with reward and motivation in mammals. However, only recently has dopamine been linked to motivated behaviour and rewarding reinforcement in fruitflies. Instead, octopamine has historically been considered to be the signal for reward in insects. Here we show, using temporal control of neural function in Drosophila, that only short-term appetitive memory is reinforced by octopamine. Moreover, octopamine-dependent memory formation requires signalling through dopamine neurons. Part of the octopamine signal requires the α-adrenergic-like OAMB receptor in an identified subset of mushroom-body-targeted dopamine neurons. Octopamine triggers an increase in intracellular calcium in these dopamine neurons, and their direct activation can substitute for sugar to form appetitive memory, even in flies lacking octopamine. Analysis of the β-adrenergic-like OCTβ2R receptor reveals that octopamine-dependent reinforcement also requires an interaction with dopamine neurons that control appetitive motivation. These data indicate that sweet taste engages a distributed octopamine signal that reinforces memory through discrete subsets of mushroom-body-targeted dopamine neurons. In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought.

原文地址

http://www.nature.com/nature/journal/v492/n7429/full/nature11614.html

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