来自德国德累斯顿工业大学的研究人员发现损伤诱导的炎症反应可促进受损的斑马鱼大脑发生再生性神经发生,从而修复受损的大脑。这项研究可为人类创伤性脑损伤及神经退行性疾病提供潜在的治疗策略。

-2012年12月7日《科学》

中文翻译


【题目】急性炎症引起受损的斑马鱼大脑发生再生性神经修复

【译文】斑马鱼大脑受损后,它能够修复受损大脑,因此斑马鱼是一种有价值的模式生物,可用于研究引起再生性神经发生的作用机制,这个机制在哺乳动物中难以证明。然而,鱼类中起始这类再生反应的信号机制还是未知的。本研究通过脑室显微注射致免疫颗粒和免疫抑制试验,发现炎症反应是提高神经前体细胞的增殖及随后的神经发生的充分必要条件。炎症反应可通过激活损伤诱导的分子程序(创伤性脑损伤后可观察到的现象),引起神经组织再生。本研究也鉴定到半胱氨酰白三烯分子是参与成年斑马鱼脑再生的炎症反应的必需组分。总之,本研究证实相比哺乳动物,斑马鱼的炎症反应是中枢神经系统中神经再生的正调节因素。

英文原稿


[Title]: Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain

[Authors]: Nikos Kyritsis, Caghan Kizil, Sara Zocher, Volker Kroehne, Jan Kaslin, Dorian Freudenreich, Anne Iltzsche, and Michael Brand

[Abstract]: The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.

原文地址

http://www.sciencemag.org/content/338/6112/1353.short

本站声明: 生物文库所有文章欢迎转载,所有文章未说明,均属于原创,转载均请注明出处。
本文链接: http://www.bioku.cn/201302/science-acute-inflammation-cysteinyl-leukotriene-regenerative-neurogenesis/
版权所有: 生物文库 - 生物医学、生物技术核心期刊文摘

留言


6 × = 六


沪ICP备12028140号
点击这里给我发消息   点击这里给我发消息