来自美国约翰霍普金斯大学霍华德休斯医学中心的研究人员发现雄性激素引起脑源性神经营养因子(BDNF)受体TrkB蛋白的表达水平发生变化,导致神经元信号通路受阻和去神经支配,从而形成雄性特有的神经回路。

-2012年12月7日《科学》

中文翻译


【题目】性别二态性的BDNF信号通路决定乳腺的感觉神经支配

【译文】在机体发育过程中,两性个体如何形成与性别二态性器官相关的神经回路,相关的机制仍然是未知的。本研究发现小鼠乳腺感觉神经支配的性别二态性作用模型及其形成机制。脑源性神经营养因子(BDNF),来源于乳腺间质,它的信号通过感觉轴突上的受体TrkB蛋白传递。研究发现BDNF是在个体早期发育阶段中确立两性乳腺感觉神经支配的决定因子。随后发现,雄性个体的雄激素促进乳腺间叶细胞表达截短型的TrkB蛋白,结果阻止感觉轴突上的BDNF-TrkB信号传递,导致乳腺神经支配快速丢失,且这种丢失与神经细胞凋亡无关。总之,受性激素调控的神经营养因子信号决定性别二态性的轴突生长和维持,从而形成性别特异性的神经回路。

英文原稿


[Title]: Sexually Dimorphic BDNF Signaling Directs Sensory Innervation of the Mammary Gland

[Authors]: Yin Liu, Michael Rutlin, Siyi Huang, Colleen A. Barrick, Fan Wang, Kevin R. Jones, Lino Tessarollo, and David D. Ginty

[Abstract]: How neural circuits associated with sexually dimorphic organs are differentially assembled during development is unclear. Here, we report a sexually dimorphic pattern of mouse mammary gland sensory innervation and the mechanism of its formation. Brain-derived neurotrophic factor (BDNF), emanating from mammary mesenchyme and signaling through its receptor TrkB on sensory axons, is required for establishing mammary gland sensory innervation of both sexes at early developmental stages. Subsequently, in males, androgens promote mammary mesenchymal expression of a truncated form of TrkB, which prevents BDNF-TrkB signaling in sensory axons and leads to a rapid loss of mammary gland innervation independent of neuronal apoptosis. Thus, sex hormone regulation of a neurotrophic factor signal directs sexually dimorphic axonal growth and maintenance, resulting in generation of a sex-specific neural circuit.

原文地址

http://www.sciencemag.org/content/338/6112/1357.abstract

本站声明: 生物文库所有文章欢迎转载,所有文章未说明,均属于原创,转载均请注明出处。
本文链接: http://www.bioku.cn/201302/science-bdnf-trkb-sexually-dimorphic-sensory-innervation/
版权所有: 生物文库 - 生物医学、生物技术核心期刊文摘

留言


六 − 4 =


沪ICP备12028140号
点击这里给我发消息   点击这里给我发消息