science20121214-6

来自德国马普学会老年研究所的研究人员阐明了延长动物寿命的机制,他们发现若移除来自秀丽隐杆线虫(Caenorhabditis elegans)性腺,则会触发机体的发育调控开关,let-7 miRNA分子信号逐步激活下游信号通路,最终延长寿命。

-2012年12月14日《科学》


中文翻译


【题目】类固醇受体-MicroRNA发育开关接收来自性腺的信号调控寿命

【译文】尽管性腺主要在生殖作用中发挥功能,但研究发现性腺也能影响动物的寿命。本研究发现移除秀丽隐杆线虫(Caenorhabditis elegans)的生殖系细胞后,就触发机体的发育调控开关,导致线虫寿命延长,同时指派组分参与幼虫发育定时信号回路。这些组分包括DAF-12类固醇受体,它参与幼虫L2期向L3期的转变,还能上调let-7微小RNA(miRNA)家族成员的水平。miRNAs靶定一个早期幼虫核因子lin-14akt-1/激酶,因此激活DAF-16/FOXO信号通路,最终延长寿命。本研究表明后生动物通过一些发育定时蛋白将性腺器官与其寿命联系起来。

英文原稿


[Title]: A Steroid Receptor–MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad    

[Authors]: Yidong Shen, Joshua Wollam, Daniel Magner, Oezlem Karalay, and Adam Antebi

[Abstract]: Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two–to–stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer.

原文地址

http://www.sciencemag.org/content/338/6113/1472.short

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