science20130201-2_副本

来自美国华盛顿大学的Michelle Smith及其同事调查了来自马拉维的317对双胞胎3岁前的营养状况。他们对夸希奥科病患病不一致的双胞胎体内的肠道微生物组进行基因组分析。借助时间序列宏基因组,他们发现以花生为基础的即用型治疗食品(RUTF)可用于治疗夸希奥科病这种急性营养不良症。

-2013年2月1日《科学》

中文翻译


【题目】肠道微生物导致严重营养不良

【译文】夸希奥科病是一种未知的重症急性营养不良症,不适当的营养素摄取加上额外的环境因子造成了这种病。为了研究大肠微生物组对这种疾病的影响,本课题组调查了317对马拉维双胞胎3岁之前的营养状况。在这一段时间内,一半比例的双胞胎营养状况良好,而43%的双胞胎之间出现营养状况不一致的情况,7%的双胞胎两个均被确诊为急性营养不良。患病状况不一致的双胞胎中的两个孩子均使用以花生为基础的即用型治疗食品(RUTF)进行治疗。时间序列宏基因组研究揭示,病人服用RUTF后,病人的肠道微生物组出现短暂良好的代谢,而当停止服用RUTF时,肠道微生物组的代谢能力衰退。本研究将一些来自双胞胎中预先冰冻的粪便微生物群体分别转移到不同的无菌小鼠中。按照马拉维人的饮食习惯喂食受体小鼠(接种了希奥科病病人的微生物组),结果导致受体小鼠体重明显减小,连同它们的氨基酸、糖类和中间代谢出现扰动,当使用RUTF后,可短暂减轻上述病症。这些发现表明大肠微生物组是夸希奥科病的致病因素。

英文原稿


[Title]: Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

[Authors]: Michelle I. Smith, Tanya Yatsunenko, Mark J. Manary, Indi Trehan, Rajhab Mkakosya, Jiye Cheng, Andrew L. Kau, Stephen S. Rich, Patrick Concannon, Josyf C. Mychaleckyj, Jie Liu, Eric Houpt, Jia V. Li, Elaine Holmes, Jeremy Nicholson, Dan Knights, Luke K. Ursell, Rob Knight, and Jeffrey I. Gordon

[Abstract]: Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well nourished, whereas 43% became discordant, and 7% manifested concordance for acute malnutrition. Both children in twin pairs discordant for kwashiorkor were treated with a peanut-based, ready-to-use therapeutic food (RUTF). Time-series metagenomic studies revealed that RUTF produced a transient maturation of metabolic functions in kwashiorkor gut microbiomes that regressed when administration of RUTF was stopped. Previously frozen fecal communities from several discordant pairs were each transplanted into gnotobiotic mice. The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. These findings implicate the gut microbiome as a causal factor in kwashiorkor.

原文地址

http://www.sciencemag.org/content/339/6119/548.short

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