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日前,来自斯坦福大学医学院(Stanford University School of Medicine)的研究人员在《Nature-Medicine》杂志上报告称,他们在对白鼠的实验中可能发现了如何减缓老化进程,以及甚至实现“返老还童”的方法

                                                                                                                                                                -2014年6月20日《自然-医学》

中文翻译


【题目】 注射年轻小鼠血液可改变与年龄相关的认知功能障碍和突触可塑性

【译文】 由于人类寿命的延长,越来越多的人正面临与年龄相关的认知障碍,因此找出一种可以对抗衰老影响的方法日益重要。本研究在分子,结构,功能和认知水平上,揭示老年生物注输年轻血液后,可消除和逆转大脑衰老所带来的相关脑功能损伤。年幼生物与年老生物的循环系统相互连接形成异时异种共生体,对这种异种共生体进行全基因组微阵列分析,确定了年老的小鼠海马中突触相关的转录改变。这种改变主要表现为成熟的神经元的树突棘的密度会增加,以及突触可塑性会增强。在可认知的水平下,年老小鼠全身注输年轻血浆后,进行场景性条件恐惧训练和空间学习记忆训练,发现其年龄所引起的认知损伤会有明显地改善。从提高结构和认知水平方面,可知输入年轻血液可以调节并在某种程度上活化年老海马的cAMP反应元件结合蛋白(Creb)。结构和认知功能方面的增强是由于年轻血液的注入介导的,并且一定程度上是由于cAMP反应元件结合蛋白(Creb)的活化引起的。我们的数据显示注入了年轻血液的年老小鼠在晚期的生活中可恢复突触可塑性并提高认知机能。

英文原稿


[Title]: Young blood reverses agerelated impairments in cognitive function and synaptic plasticity in mice

[Authors]:  Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher, Jian Luo, Lucas K Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A Simmons, Xinmin S Xie, Frank M Longo & Tony Wyss-Coray.

[Abstract]: 

As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Genome-wide microarray analysis of heterochronic parabionts-in which circulatory systems of young and aged animals are connected-identified synaptic plasticity-related transcriptional changes in the hippocampus of agedmice. Dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. At the cognitive level, systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory. Structural and cognitive enhancements elicited by exposure to young blood are mediated, in part, by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.

原文地址: http://www.ncbi.nlm.nih.gov/pubmed/24793238

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