研究人员对赤道几内亚的非洲国家刚果民主共和国的埃博拉病毒性疾病爆发情况进行研究,发现目前在DRC爆发的EVD与之前在赤道几内亚非洲爆发的EVD有相似的临床和流行病学特点。本次的病原体是当地的EBOV变种,来源于人畜共患的种属,与2014年西非流行的种类不同。

20141015日《新英格兰医学杂志》

中文翻译


 

【题目】刚果民主共和国的埃博拉病毒性疾病情况

【译文】

背景:自2014726日开始,赤道几内亚的非洲国家刚果民主共和国(DRC)已经报道了7次埃博拉病毒性疾病(EVD)爆发,这是继EVD在西非蔓延后的又一次大规模流行。在赤道几内亚和西非同时报道了EVD的发生,使我们提出疑问,这两次爆发之间是否有关联。

方法:我们使用世界卫生组织临床调查病毒性出血热的标准问卷,从DRC获得病人的数据。病人分为疑似病例、可能病例、确诊EVD病例和非EVD病人。使用血液样本做多聚酶链反应为基础的诊断、病毒分离、序列分析和系统进化分析。

结果:本次爆发开始于Équateur省Boende镇附近的Inkanamongo村,并且限制在该省。在2014726日至107日,共报告了69名疑似、可能和确诊病人,包括8例医务人员感染,其中49人死亡。到107日,从EVD爆发以来,病毒大约传了6代。在817日到24日,每周报告的新发病例数到达高峰,之后明显下降。基因组测序表明埃博拉病毒(EBOV,扎伊尔种)是本次该病爆发的原因。对从本次爆发流行中分离出来的EBOV,进行完整编码的基因序列分析,结果显示,99.2%1995年在DRCKikwit爆发的病毒变种极为相关,96.8%与西非正在流行的变种极为相关。

结论:目前在DRC爆发的EVD与之前在赤道几内亚非洲爆发的EVD有相似的临床和流行病学特点。本次的病原体是当地的EBOV变种,来源于人畜共患的种属,与2014年西非流行的种类不同。

【关键词】埃博拉,刚果,爆发

 

英文原稿


 

[Title] Ebola Virus Disease in the Democratic Republic of Congo
[Authors] Maganga GD, Kapetshi J, Berthet N, Ilunga BK, M D FK, Kingebeni PM, et al.
[Abstract]

Background: The seventh reported outbreak of Ebola virus disease (EVD) in the equatorial African country
of the Democratic Republic of Congo (DRC) began on July 26, 2014, as another large EVD epidemic
continued to spread in West Africa. Simultaneous reports of EVD in equatorial and West Africa raised the
question of whether the two outbreaks were linked.
Methods: We obtained data from patients in the DRC, using the standard World Health Organization
clinical-investigation form for viral hemorrhagic fevers. Patients were classified as having suspected,
probable, or confirmed EVD or a non-EVD illness. Blood samples were obtained for polymerase-
chain-reaction-based diagnosis, viral isolation, sequencing, and phylogenetic analysis.
Results: The outbreak began in Inkanamongo village in the vicinity of Boende town in Équateur province
and has been confined to that province. A total of 69 suspected, probable, or confirmed cases were
reported between July 26 and October 7, 2014, including 8 cases among health care workers, with 49
deaths. As of October 7, there have been approximately six generations of cases of EVD since the
outbreak began. The reported weekly case incidence peaked in the weeks of August 17 and 24 and
has since fallen sharply. Genome sequencing revealed Ebola virus (EBOV, Zaire species) as the cause
of this outbreak. A coding-complete genome sequence of EBOV that was isolated during this outbreak
showed 99.2% identity with the most closely related variant from the 1995 outbreak in Kikwit in the
DRC and 96.8% identity to EBOV variants that are currently circulating in West Africa.
Conclusions: The current EVD outbreak in the DRC has clinical and epidemiologic characteristics that
are similar to those of previous EVD outbreaks in equatorial Africa. The causal agent is a local EBOV
variant, and this outbreak has a zoonotic origin different from that in the 2014 epidemic in West Africa.

[Keywords] Ebola, Congo, outbreak

 

原文地址:

http://www.nejm.org/doi/full/10.1056/NEJMoa1411099

 

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